Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | MNX1-AS1, CCAT5 |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, other |
| Sample | cervical cancer tissues and cell lines (Hela, SW765, C33A,SiHa, ME180) |
| Expression Pattern | up-regulated |
| Function Description | Results showed that the proliferation of Hela cells was significantly inhibited and apoptosis enhanced by the transfection of shMNX1-AS1, while overexpressing MNX1-AS1 in E6E7 cells presented the contrary results. As for mechanism investigation, it was demonstrated that overexpression of MNX1-AS1 significantly improved the expression of p-ERK1/2 and p-JNK. And the effects of MNX1-AS1 on cell proliferation and apoptosis would be diminished after inactivating the phosphorylation of either ERK or JNK. |
| Pubmed ID | 30302806 |
| Year | 2019 |
| Title | LncRNA MNX1-AS1 Promotes the Progression of Cervical Cancer Through Activating MAPK Pathway |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |