Basic Information
| LncRNA/CircRNA Name | MNX1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:157010805-157016426 |
| Ensemble | ENSG00000243479 |
| Refseq | NR_038835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | tumor tissues and normal adjacent lung tissues ,non-small cell lung cancer cell line A549 ,human normal lung epithelial cell line Beas-2B |
| Expression Pattern | up-regulated |
| Function Description | Compared with normal lung tissue, the expression of MNX1-AS1 was significantly increased in lung cancer tissues. The expression level of MNX1-AS1 in NSCLC cell line A549 was significantly higher than that in human normal lung epithelial cell line Beas-2B.MNX1-AS1 expression was significantly associated with TNM stage and lymph node metastasis.High expression of MNX1-AS1 was associated with a poor prognosis in NSCLC.Knockdown of MNX1-AS1 inhibited proliferation, migration and invasion of the NSCLC cell line A549 and promoted apoptosis. |
| Pubmed ID | 31118668 |
| Year | 2019 |
| Title | Expression and significance of LncRNA MNX1-AS1 in non-small cell lung cancer |
External Links
| Links for MNX1-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |