Basic Information
| LncRNA/CircRNA Name | MIR503HG |
| Synonyms | NA |
| Region | GRCh38_X:134543337-134546632 |
| Ensemble | ENSG00000223749 |
| Refseq | NR_024607 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot |
| Sample | NSCLC tissues,NSCLC cell lines H1299, SPCA1, A549, and human bronchial epithelioid cell line 16HBE |
| Expression Pattern | down-regulated |
| Function Description | MIR503HG was downregulated in NSCLC. CCK-8 assay and colony formation assay revealed that MIR503HG negatively regulated cell proliferation in NSLCL progression. In addition, MIR503HG promoted cell apoptosis and suppressed cell cycle progression in NSCLC in vitro. MIR503HG inhibited tumor formation in nude mice bearing NSCLC in vivo. MIR503HG downregulated Wnt1 expression in NSCLC. |
| Pubmed ID | 31858550 |
| Year | 2019 |
| Title | Long Non-Coding RNA MIR503HG Serves as a Tumor Suppressor in Non-Small Cell Lung Cancer Mediated by wnt1 |
External Links
| Links for MIR503HG | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |