Basic Information
| LncRNA/CircRNA Name | MIR4697HG |
| Synonyms | MIR4697 host gene |
| Region | GRCh38_11:133896438-133901601 |
| Ensemble | ENSG00000280237 |
| Refseq | NR_024344 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter analysis, RIP |
| Sample | Glioma cell lines (U343, Hs683, LN25, A172, LN18, U87, U251) and normal cell lines (NHA) |
| Expression Pattern | down-regulated |
| Function Description | The expression of MIR4697HG is down-regulated significantly in glioma cells due to the up-regulated expression of RAD21. MiR-766-5p was identified functioning as a sponge for MIR4697HG and is sequestered by MIR4697HG. We also found either miR-766-5p inhibitor or PRR12 knockdown rescued the function depletion caused by MIR4697HG overexpression. In all, the down-regulated expression of MIR4697HG inhibited PRR12 to suppress glioma and led to the deterioration of glioma. |
| Pubmed ID | 31884342 |
| Year | 2020 |
| Title | RAD21 Inhibited Transcription of Tumor Suppressor MIR4697HG and Led to Glioma Tumorigenesis |
External Links
| Links for MIR4697HG | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |