Basic Information
| LncRNA/CircRNA Name | MIR4435-2HG |
| Synonyms | NA |
| Region | GRCh38_2:111036776-111523376 |
| Ensemble | ENSG00000172965 |
| Refseq | NR_015395 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR etc. |
| Sample | promotes cancer tissues and adjacent healthy tissues, HCC cell lines(SNU-398 and SNU-182) |
| Expression Pattern | up-regulated |
| Function Description | MIR4435-2HG and miRNA-487a were upregulated in tumor tissues compared to adjacent healthy tissues from HCC patients. The expression of MIR4435-2HG was significantly affected by tumor size but not by tumor metastasis. Correlation analysis showed that MIR4435-2HG and miRNA-487a were positively correlated in both the tumor tissues and adjacent healthy tissues from HCC patients. Overexpression of MIR4435-2HG led to upregulation of miRNA-487a in the cells of HCC cell lines, while overexpression of miRNA-487a did not significantly affect MIR4435-2HG. Overexpression of MIR4435-2HG and miRNA-487a promoted the proliferation of cells of HCC cell lines, and miRNA-487a knockdown partially attenuated the enhancing effects of MIR4435-2HG overexpression on cancer cell proliferation. |
| Pubmed ID | 30988676 |
| Year | 2019 |
| Title | The lncRNA MIR4435-2HG Is Upregulated in Hepatocellular Carcinoma and Promotes Cancer Cell Proliferation by Upregulating miRNA-487a |
External Links
| Links for MIR4435-2HG | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |