Basic Information
| LncRNA/CircRNA Name | MIR4435-2HG |
| Synonyms | NA |
| Region | GRCh38_2:111036776-111523376 |
| Ensemble | ENSG00000172965 |
| Refseq | NR_015395 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | melanoma tissues,cell lines (A375 and A2058) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of lncRNA MIR4435-2HG was identified in melanoma and promoted melanoma cell proliferation, migration and invasion. In addition, lncRNA MIR4435-2HG serves as the ceRNA of miR-802. MiR-802 inhibited melanoma progression by downregulating lncRNA MIR4435-2HG. Besides, miR-802 directly targets FLOT2. And knockdown of FLOT2 restrained the progression of melanoma by downregulating lncRNA MIR4435-2HG and upregulating miR-802. |
| Pubmed ID | 32196611 |
| Year | 2020 |
| Title | Long Non-Coding RNA MIR4435-2HG Recruits miR-802 From FLOT2 to Promote Melanoma Progression |
External Links
| Links for MIR4435-2HG | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |