Basic Information
| LncRNA/CircRNA Name | MIR31HG |
| Synonyms | loc554202, |
| Region | GRCh38_9:21455642-21559669 |
| Ensemble | ENSG00000171889 |
| Refseq | NR_027054 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | NSCLC tissue, Human NSCLC cells H1299, A549, H1975 and H460 and a normal human lung epithelial cell line BEAS-2B |
| Expression Pattern | up-regulated |
| Function Description | SP1-induced MIR31HG was significantly upregulated in NSCLC tissues and cell lines. Moreover, Cox multivariate survival analysis revealed that high MIR31HG was an independent predictor of poor overall survival(OS). Functionally, knockdown of TINCR obviously suppressed NSCLC cells migration and invasion in vitro and inhibited NSCLC cells metastasis in vivo. Mechanistically, we identified MIR31HG could act as a miR-214 sponge using RNA pull down, luciferase reporter and RIP assays. Lastly, we verified that overexpression of MIR31HG effectively reverses miR-214-induced inhibition of NSCLC cells progression. |
| Pubmed ID | 30659947 |
| Year | 2019 |
| Title | Long noncoding RNA MIR31HG is activated by SP1 and promotes cell migration and invasion by sponging miR-214 in NSCLC |
External Links
| Links for MIR31HG | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |