Basic Information
| LncRNA/CircRNA Name | MIR31HG |
| Synonyms | NA |
| Region | GRCh38_9:21455642-21559669 |
| Ensemble | ENSG00000171889 |
| Refseq | NR_027054 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | OS tissues and adjacent non-tumor tissues ,OS cell lines(143B, MG63, U2OS and Saos-2 cells) ,human osteoblastic cell line hFOB1.19 cells |
| Expression Pattern | up-regulated |
| Function Description | MIR31HG was upregulated in OS tissues and OS cell lines.The patients with high expression of MIR31HG have high tumor stages and distant metastasis.Knockdown of MIR31HG restored the expression of miR-361. Restoration of miR-361 level in Saos-2 and U2OS cells induced cell apoptosis and G1/S arrest, inhibited proliferation and migration, which was, however, abrogated by MIR31HG.Cell growth and metastasis-related target genes of MIR-361 including VEGF, FOXM1 and Twist were de-repressed in OS cells by MIR31HG overexpression, leading to upregulated BCL2, CCND1 and epithelial-mesenchymal transition (EMT) phenotype.Overexpression of MIR31HG in vivo also promoted tumor growth via inhibition of miR-361 signals and elevated the expression of VEGF, FOXM1 and Twist for tumor growth. |
| Pubmed ID | 31564967 |
| Year | 2019 |
| Title | Long Noncoding RNA MIR31HG Abrogates the Availability of Tumor Suppressor microRNA-361 for the Growth of Osteosarcoma |
External Links
| Links for MIR31HG | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |