Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Cell transfection, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | PTC tissues, cell lines (TPC-1, K1, BCPAP and CGTH-W3) |
| Expression Pattern | down-regulated |
| Function Description | BANCR levels are lower in PTC tumor tissues than control tissues. Decreased BANCR levels correlate with tumor size, the presence of multifocal lesions and advanced PTC stage. BANCR overexpression reduced PTC cell proliferation and promoted apoptosis, which inhibited metastasis. It also inactivated ERK1/2 and p38, and this effect was enhanced by treatment with the MEK inhibitor U0126. Finally, BANCR overexpression dramatically inhibited tumor growth from PTC cells in xenograft mouse models. |
| Pubmed ID | 27462868 |
| Year | 2016 |
| Title | BRAF-activated LncRNA functions as a tumor suppressor in papillary thyroid cancer. |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |