Basic Information
LncRNA/CircRNA Name | MIR210HG |
Synonyms | NA |
Region | GRCh38_11:565660-568457 |
Ensemble | ENSG00000247095 |
Refseq | NR_038262 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | non small cell lung cancer |
ICD-0-3 | C34 |
Methods | qRT-PCR , Western blot , RIP etc. |
Sample | NSCLC primary and paracancerous tissues ,Normal human bronchial epithelial cell line (BEAS-2B) ,lung cancer cell lines (A549,H1299, and H1975) |
Expression Pattern | up-regulated |
Function Description | MIR210HG was highly expressed in NSCLC tissues.MIR210HG expression was correlated to tumor stage and lymph node metastasis of NSCLC patients.Besides, lower disease-free survival (DFS) and overall survival (OS) were found in NSCLC patients with high-level MIR210HG compared with those with low-level MIR210HG.MIR210HG knockdown remarkably inhibited proliferation and migration of NSCLC cells. MIR210HG could recruit DNMT1, thereafter promoting methylation of CACNA2D2 promoter region. CACNA2D2 overexpression remarkably inhibited cell proliferation. Moreover, inhibited proliferation induced by MIR210HG knockdown was reversed by CACNA2D2 knockdown. |
Pubmed ID | 31190878 |
Year | 2019 |
Title | LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1 |
External Links
Links for MIR210HG | GenBank HGNC NONCODE |
Links for non small cell lung cancer | OMIM COSMIC |