Basic Information
| LncRNA/CircRNA Name | MIR205HG |
| Synonyms | NA |
| Region | GRCh38_1:209428820-209432838 |
| Ensemble | ENSG00000230937 |
| Refseq | NR_145433 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, RIP |
| Sample | CC (cervical cancer) cell lines (CaSki, MS751, HeLa and SiHa) as well as normal cervical cell line HcerEpic |
| Expression Pattern | up-regulated |
| Function Description | t was observed from mechanism experiments that MIR205HG depleted SRSF1 to increase KRT17 expression. The whole mechanism of MIR205HG/SRSF1/KRT17 axis affecting cell proliferation, apoptosis and migration in cervical cancer was validated using rescue assays. In conclusion, MIR205HG modulated the biological activities of cervical cancer cells via targeting SRSF1 and regulating KRT17. |
| Pubmed ID | 31655037 |
| Year | 2019 |
| Title | Long Non-Coding RNA MIR205HG Regulates KRT17 and Tumor Processes in Cervical Cancer via Interaction With SRSF1 |
External Links
| Links for MIR205HG | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |