Basic Information
| LncRNA/CircRNA Name | MIR17HG |
| Synonyms | NA |
| Region | GRCh38_13:91347820-91354579 |
| Ensemble | ENSG00000215417 |
| Refseq | NR_027349 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | glioma tissues, Human glioma cell lines (U87, U251) and human embryonic kidney (HEK) 293 T cells |
| Expression Pattern | up-regulated |
| Function Description | FXR1and MIR17HG were upregulated in glioma tissues and cell lines. Downregulation of FXR1 or MIR17HG resulted in inhibition of glioma cells progression. We also found that FXR1 regulates the biological behavior of glioma cells via stabilizing MIR17HG. In addition, downregulated MIR17HG increased miR-346/miR-425-5p expression and MIR17HG acted as ceRNA to sponge miR-346/miR-425-5p. TAL1 was a direct target of miR-346/miR-425-5p, and played oncogenic role in glioma cells. More importantly, TAL1 activated MIR17HG promoter and upregulated its expression, forming a feedback loop. Remarkably, FXR1 knockdown combined with inhibition of MIR17HG resulted in the smallest tumor volumes and the longest survivals of nude mice in vivo. |
| Pubmed ID | 30691465 |
| Year | 2019 |
| Title | FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG |
External Links
| Links for MIR17HG | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |