Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | HCC tissues, cell lines (HuH-7, Hep3B, HepG2, and H2-M) |
| Expression Pattern | up-regulated |
| Function Description | BANCR expression was remarkably increased in HCC tissues compared with adjacent noncancerous tissues. BANCR expression in four HCC cell lines was also significantly upregulated. Clinicopathologic analysis revealed that high BANCR expression correlated with high tumor grade, large tumor size, venous infiltration, advanced tumor, node, and metastasis (TNM) stage, and shorter overall survival. Moreover, BANCR downregulation in Hep3B cells impaired cell proliferation, promoted cell apoptosis, reduced cell invasion and migration, led to downregulated vimentin, and upregulated E-cadherin protein levels. |
| Pubmed ID | 26758762 |
| Year | 2016 |
| Title | Increased expression of LncRNA BANCR and its prognostic significance in human hepatocellular carcinoma. |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |