Basic Information
| LncRNA/CircRNA Name | MIR155HG |
| Synonyms | NA |
| Region | GRCh38_21:25561909-25575168 |
| Ensemble | ENSG00000234883 |
| Refseq | NR_001458 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | Western blot, qRT-PCR |
| Sample | renal tubular epithelial cell line (HKC-5), the normal human renal cell line (HK-2), KIRC cell lines (LoMet-ccRCC and 786-O) |
| Expression Pattern | up-regulated |
| Function Description | the expression of MIR155HG was increased in ccRCC. Interference of MIR155HG inhibited the cellular functions of ccRCC cells, which was reversed by overexpression of miR-155-3p and miR-155-5p. In addition, MIR155HG interference repressed the expression of miR-155-5p and miR-155-3p in ccRCCs, while inhibition of miR-155-5p and miR-155-3p restrained the proliferation, invasion and migration of ccRCCs. |
| Pubmed ID | 31889587 |
| Year | 2020 |
| Title | Blocking lncRNA MIR155HG/miR-155-5p/-3p Inhibits Proliferation, Invasion and Migration of Clear Cell Renal Cell Carcinoma |
External Links
| Links for MIR155HG | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |