Basic Information
| LncRNA/CircRNA Name | miR143HG |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | RT-qPCR |
| Sample | LSCC cell line UM-SCC-17A,LSCC patients |
| Expression Pattern | down-regulated |
| Function Description | miR143HG was downregulated in LSCC and inversely correlated with miR-21. In LSCC cells, miR143HG overexpression led to the downregulated expression of miR-21, whereas miR-21 overexpression failed to affect miR143HG. Methylation-specific PCR results showed that miR143HG overexpression led to increased methylation of miR-21. Low expression levels of miR143HG were correlated with poor survival. Overexpression of miR143HG led to decreased, whereas miR-21 overexpression resulted in increased rate of LSCC cell migration and invasion. |
| Pubmed ID | 31872875 |
| Year | 2019 |
| Title | LncRNA miR143HG Suppresses miR-21 Through Methylation to Inhibit Cell Invasion and Migration |
External Links
| Links for miR143HG | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |