Basic Information
| LncRNA/CircRNA Name | MIR100HG |
| Synonyms | MIR100HG, AGD1, linc-NeD125, lncRNA-N2 |
| Region | GRCh38_11:122028327-122556721 |
| Ensemble | ENSG00000255248 |
| Refseq | NR_024430 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | RNA-seq, qPCR, Western blot etc. |
| Sample | cell lines (BxPC-3, PANC-1 and COLO357) |
| Expression Pattern | up-regulated |
| Function Description | although the pro-tumourigenic miR-100 and miR-125b accordingly increase,the amount of anti-tumourigenic let-7a is unchanged, as TGF-B also induces LIN28B inhibiting its maturation.Notably, we demonstrate that inactivation of miR-125b or miR-100 affects the TGF-B-mediated response indicating that these miRNAs are important TGF-B effectors.We integrate AGO2-RIP-seq with RNA-seq to identify the global regulation exerted by these miRNAs in PDAC cells.Transcripts targeted by miR-125b and miR-100 significantly overlap and mainly inhibit p53 and cell-cell junctions'pathways.Together, we uncover that TGF-B induces an lncRNA, whose encoded miRNAs, miR-100, let-7a and miR-125b play opposing roles in controlling PDAC tumourigenesis. |
| Pubmed ID | 29748571 |
| Year | 2018 |
| Title | TGF-B induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. |
External Links
| Links for MIR100HG | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |