Basic Information
| LncRNA/CircRNA Name | MIR100HG |
| Synonyms | mir-100-let-7a-2-mir-125b-1 cluster host gene |
| Region | GRCh38_11:122028327-122556721 |
| Ensemble | ENSG00000255248 |
| Refseq | NR_024430 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-qPCR |
| Sample | CRC tissues,CRC LoVo, DLD-1, RKO, SW48, HCT8 and HCT116 cell lines, and the normal intestinal mucous epithelium FHC cell line |
| Expression Pattern | up-regulated |
| Function Description | MIR100HG expression was higher in CRC tissues compared with in corresponding normal mucosa tissues.MIR100HG expression was higher in advanced CRC compared with in early stage CRC.high MIR100HG expression exhibited poorer disease-free survival and overall survival compared with patients with CRC and lower MIR100HG expression.upregulated MIR100HG expression promoted CRC cell migration and invasion and the formation of liver metastatic colonies in mice. |
| Pubmed ID | 31814848 |
| Year | 2019 |
| Title | Elevated MIR100HG Promotes Colorectal Cancer Metastasis and Is Associated With Poor Prognosis |
External Links
| Links for MIR100HG | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |