Basic Information
| LncRNA/CircRNA Name | MINCR |
| Synonyms | MINCR, LINC01604 |
| Region | GRCh38_8:143280161-143281690 |
| Ensemble | ENSG00000253716 |
| Refseq | NR_120682 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | B-cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Lentiviral infection, ChIP etc. |
| Sample | cell lines (hT-RPE-MycER) |
| Expression Pattern | up-regulated |
| Function Description | We focused on a lncRNA that we named MYC-induced long noncoding RNA (MINCR), showing a strong correlation with MYC expression in MYC-positive lymphomas. To understand its cellular role, we performed RNAi and found that MINCR knockdown is associated with an impairment in cell cycle progression. Differential gene expression analysis after RNAi showed a significant enrichment of cell cycle genes among the genes down-regulated after MINCR knockdown. Interestingly, these genes are enriched in MYC binding sites in their promoters, suggesting that MINCR acts as a modulator of the MYC transcriptional program. Accordingly, MINCR knockdown was associated with a reduction in MYC binding to the promoters of selected cell cycle genes. |
| Pubmed ID | 26351698 |
| Year | 2015 |
| Title | MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. |
External Links
| Links for MINCR | GenBank HGNC NONCODE |
| Links for B-cell lymphoma | OMIM COSMIC |