Basic Information
| LncRNA/CircRNA Name | MINCR |
| Synonyms | MINCR, LINC01604 |
| Region | GRCh38_8:143280161-143281690 |
| Ensemble | ENSG00000253716 |
| Refseq | NR_120682 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RIP, Dual luciferase reporter assay etc. |
| Sample | gallbladder carcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | High MINCR expression levels in GBC were positively associated with tumor volume and lymph node metastasis and were negatively correlated with overall survival (OS). Upregulation of MINCR and enhancer of zeste homolog 2 (EZH2) in GBC coincided with the downregulation of miR-26a-5p in GBC. Mechanistically, MINCR/miR-26a-5p/EZH2 axis was found to be involved in cell proliferation, cell invasive and apoptosis in GBC cells. Moreover, knockdown of MINCR suppressed cell proliferation, decreased S-phase cell numbers, increased cell apoptosis, and inhibited cell invasion by inhibiting the epithelial-mesenchymal transition (EMT) phenomenon in GBC cells. |
| Pubmed ID | 27345740 |
| Year | 2016 |
| Title | Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression. |
External Links
| Links for MINCR | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |