Basic Information
| LncRNA/CircRNA Name | MINCR |
| Synonyms | NA |
| Region | GRCh38_8:143280161-143281690 |
| Ensemble | ENSG00000253716 |
| Refseq | NR_120682 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | NPC tissues, cell lines(CNE2 and CNE2R) |
| Expression Pattern | up-regulated |
| Function Description | MINCR was upregulated in NPC, and linked with worse prognosis and radiotherapy efficacy. MINCR intervention weakened NPC cell radioresistance. MINCR sponged miR-223 to regulate ZEB1. Inactivating AKT eliminated the increased radioresistance of CNE2 cells induced by overexpressing MINCR. |
| Pubmed ID | 31760895 |
| Year | 2019 |
| Title | LncRNA MINCR Regulates Irradiation Resistance in Nasopharyngeal Carcinoma Cells via the microRNA-223/ZEB1 Axis |
External Links
| Links for MINCR | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |