Basic Information
| LncRNA/CircRNA Name | MIF-AS1 |
| Synonyms | MIF-AS |
| Region | GRCh38_22:23894426-23898930 |
| Ensemble | ENSG00000218537 |
| Refseq | NR_038911 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, Microarray, other |
| Sample | gastric adenocarcinoma cell lines (AGS, SGC-7901) and gastric cancer tissues and cell lines (MKN28, MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | Expression of lncMIF-AS1 and NDUFA4 were upregulated in gastric cancer tissues and cells as compared with non-cancerous gastric tissues and cells (P < .05). MiR-212-5p was identified as the most important miRNA linker between lncMIF-AS1 and NDUFA4, which was negatively regulated by lncMIF-AS1 and its depletion is the main cause of NDUFA4 overexpression (P < .01). The upregulated expression of NDUFA4 then greatly promoted the proliferation and decreased the apoptosis of gastric cancer cells through activation of the oxidative phosphorylation pathway. |
| Pubmed ID | 30238562 |
| Year | 2018 |
| Title | Long Non-Coding RNA MIF-AS1 Promotes Gastric Cancer Cell Proliferation and Reduces Apoptosis to Upregulate NDUFA4 |
External Links
| Links for MIF-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |