Basic Information
| LncRNA/CircRNA Name | MIF-AS1 |
| Synonyms | NA |
| Region | GRCh38_22:23894426-23898930 |
| Ensemble | ENSG00000218537 |
| Refseq | NR_038911 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | OC tissues ,cell lines(IOSE80,OC3, HO-8910, ES-2, and SKOV-3) |
| Expression Pattern | up-regulated |
| Function Description | MIF-AS1 was significantly upregulated in OC tissues and cell lines (p<0.05). Higher level of MIF-AS1 predicted significantly worse prognosis of OC patients (p<0.05). The knockdown of MIF-AS1 markedly attenuated the proliferative, migratory, and invasive abilities of ES-2 and HO-8910 cells (p<0.05). Dual-Luciferase reporter gene assay verified that MIF-AS1 competed with PLCB1 to bind miRNA-31-5p. |
| Pubmed ID | 32196575 |
| Year | 2020 |
| Title | LncRNA MIF-AS1 Aggravates the Progression of Ovarian Cancer by Sponging miRNA-31-5p |
External Links
| Links for MIF-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |