Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | MIAT, C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RNAi etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (HepG2, Huh7, SK-HEP-1, HLE and L02) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of MIAT is related to the proliferation and invasion of HCC,and downregulating MIAT expression inhibited HCC cell proliferation and invasion.The H3/H4 histone acetylation level of MIAT promoter in HCC tissues was higher than that in normal tissues.MIAT negatively regulated miR-214 in HCC cells. Inhibition of miR-214 reversed the influence of MIAT downregulation on HCC cell proliferation and invasion.In nude mouse xenograft models,downregulation of MIAT markedly suppressed the tumor growth of HCC via releasing miR-214.In conclusion, lncRNA MIAT promotes the proliferation and invasion of HCC cells through sponging miR-214, which brings a novel target for the therapy and prognosis of hepatocellular carcinoma.NEW & NOTEWORTHY This is the first research showing long noncoding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) to have a regulatory effect on hepatocellular carcinoma. |
| Pubmed ID | 29097358 |
| Year | 2018 |
| Title | lncRNA MIAT promotes proliferation and invasion of HCC cells via sponging miR-214. |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |