Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | NA |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | osteosarcoma tissue, osteoblast cell lines hFOB (OB3) and osteosarcoma cell lines Saos-2 and MG-63 |
| Expression Pattern | up-regulated |
| Function Description | during the development of osteosarcoma, MIAT is upregulated in tumor tissues compared to adjacent non tumor tissues. The spreading and proliferation of osteosarcoma cells was reduced by MIAT knockdown. These findings indicate that MIAT functions by competing with critical RNAs to target miR 150 5p and activate zinc finger E box binding homeobox 1 to modulate the function of osteosarcoma cells. Together, the present findings may contribute to the understanding of the pathogenesis of osteosarcoma. |
| Pubmed ID | 30655889 |
| Year | 2019 |
| Title | Long non-coding RNA MIAT competitively binds miR-150-5p to regulate ZEB1 expression in osteosarcoma |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |