Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | NA |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | TSCC specimen and corresponding adjacent non-tumor tissues ,Human TSCC cell lines SCC-9 ,fast blood samples |
| Expression Pattern | up-regulated |
| Function Description | Myocardial infarction associated transcript expression level in TSCC specimen was upregulated compared to adjacent non-neoplastic tongue tissue and had a significant positive association with its level in serum.MIAT levels in both TSCC specimen and serum were correlated with cervical lymph node metastasis and histological grading of TSCC patients.Results of survival analysis showed that high expression levels of MIAT in both TSCC tissues and serums indicated higher mortality and shorter survival time of TSCC patients.MIAT could induce invasion of TSCC cells by regulating expressions of EMT markers through activation of Wnt/?-catenin signaling pathway. |
| Pubmed ID | 31166624 |
| Year | 2019 |
| Title | Long Non-Coding RNA Myocardial Infarction Associated Transcript Promotes Epithelial-Mesenchymal Transition and Is an Independent Risk Factor for Poor Prognosis of Tongue Squamous Cell Carcinoma |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for tongue squamous cell carcinoma | OMIM COSMIC |