Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | myocardial infarction associated transcript |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot analysis, Luciferase reporter assay |
| Sample | BM specimens, bone marrow stromal cell (HS-5), human AML lines (NB-4, HL-60, THP-1, MOLM-14 and KG1a) and human embryonic kidney cell line (293T) |
| Expression Pattern | up-regulated |
| Function Description | MIAT is overexpressed in AML patient specimens and AML cell lines. Importantly, upregulation of MIAT is closely related with poor clinical outcome. Further investigations reveal that knockdown of MIAT inhibits the colony formation and proliferation, meanwhile, accelerates the apoptosis of AML cells in vitro.MIAT can function as a sponge to inhibit microRNA-495 (miR-495), a tumor suppressor, in AML cells. |
| Pubmed ID | 31698307 |
| Year | 2019 |
| Title | Long Noncoding RNA MIAT Promotes the Progression of Acute Myeloid Leukemia by Negatively Regulating miR-495 |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |