Basic Information
| LncRNA/CircRNA Name | MIAT |
| Synonyms | myocardial infarction-associated transcript |
| Region | GRCh38_22:26646428-26676475 |
| Ensemble | ENSG00000225783 |
| Refseq | NR_003491 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | wilms tumor |
| ICD-0-3 | C64.9 |
| Methods | RT-qPCR, Western blot analysis |
| Sample | Wilms' tumor tissues,The human Wilms' tumor cells were collected and digested from the fresh Wilms' tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | By comparing with MIAT expression in adjacent tissues, the MIAT expression level was significantly higher in Wilms' tumor samples. Moreover, the cell growth ability of Wilms' tumor cells was inhibited due to the loss of MIAT. The migrated and invaded ability of the Wilms' tumor cells was inhibited due to the loss of MIAT. Furthermore, the expression of DGCR8 was downregulated due to the loss of MIAT. |
| Pubmed ID | 31841180 |
| Year | 2019 |
| Title | Long Noncoding RNA MIAT Acts as an Oncogene in Wilms' Tumor Through Regulation of DGCR8 |
External Links
| Links for MIAT | GenBank HGNC NONCODE |
| Links for wilms tumor | OMIM COSMIC |