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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	melanoma
ICD-0-3	NA
Methods	qPCR, Luciferase reporter assay, Western blot
Sample	melanoma tissues, cells lines (A375, A875 and M14, and human epidermal melanocytes)
Expression Pattern	up-regulated
Function Description	the expression of the BANCR was low in melanocytic nevus and human melanocytes but high in melanoma tissues and cell lines. Knockdown of BANCR inhibited melanoma cell proliferation and invasion, and induced cell apoptosis.the inhibitory effect of BANCR siRNA in cell growth and migration.miR-204 was a direct target of BANCR and neurogenic locus notch homolog protein 2 (Notch2) was a direct target of miR-204. BANCR may promote melanoma cell growth through inhibition of miR-204, leading to the activation of Notch2 pathway. BANCR knockdown inhibited tumor growth in vivo.
Pubmed ID	29075789
Year	2017
Title	BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR-204.

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