Basic Information
| LncRNA/CircRNA Name | MFI2-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | Glioma cell lines (U251, SHG-44, TJ905, and U87) and normal astrocyte cell NHA, glioma tissues and normal tissues |
| Expression Pattern | up-regulated |
| Function Description | MFI2-AS1 was markedly overexpressed in glioma cells and clinical tissues. The higher level of MFI2-AS1 is related to the poor prognosis in patients with glioma. Furthermore, the downregulation of MFI2-AS1 suppresses the growth, aggressiveness, and induces apoptosis of glioma cells. Also, MMP14 is the target gene of miR-485-5p and its level is positively modulated by MFI2-AS1. The rescue experiments reveal that miR-485-5p inhibition reverses the suppressive impacts of MFI2-AS1 silencing on the growth, migration, and invasive abilities of glioma cells. Finally, we elaborate that MFI2-AS1 silencing represses glioma cell growth in vivo and suppress the expression of MMP14 |
| Pubmed ID | 31298339 |
| Year | 2019 |
| Title | MFI2-AS1 regulates the aggressive phenotypes in glioma by modulating MMP14 via a positive feedback loop |
External Links
| Links for MFI2-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |