Basic Information
| LncRNA/CircRNA Name | MFI2 |
| Synonyms | MELTF, CD228, MAP97, MFI2, MTF1, MTf |
| Region | GRCh38_3:196987559-197029816 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell migration and invasion assay etc. |
| Sample | osteosarcoma tissues, cell lines (SAOS-2, MG63, U-2OS) |
| Expression Pattern | up-regulated |
| Function Description | We found that the lncRNA MFI2 was significantly overexpressed in human osteosarcoma tissues. Knockdown of lncRNA MFI2 expression suppressed MG63 and SAOS-2 cell proliferation, migration and invasion, and induced cell apoptosis. Furthermore, the expression of forkhead box P4 (FOXP4) was significantly increased and it was positively associated with lncRNA MFI2 expression in tumor tissues. In addition, knockdown of FOXP4 expression by RNA interference strategy inhibited osteosarcoma cell proliferation, migration and invasion, and promoted cell apoptosis. All the results indicated lncRNA MFI2 could promote proliferation and migration of osteosarcoma cells by regulating FOXP4 expression. |
| Pubmed ID | 27513470 |
| Year | 2016 |
| Title | Overexpression of long non-coding RNA MFI2 promotes cell proliferation and suppresses apoptosis in human osteosarcoma. |
External Links
| Links for MFI2 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |