Basic Information
| LncRNA/CircRNA Name | METTL14 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-PCR, Western blot, RNA immunoprecipitation |
| Sample | CRC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | XIST exhibited higher levels in cancer compared to normal tissues. Additionally, enhanced cell growth and invasion induced by METTL14 knockdown could be attenuated by XIST inhibition. These results directly showed that METTL14 promotes m6A-methylation of XIST, resulting in downregulation of this lncRNA and suppression of CRC proliferation and invasion. |
| Pubmed ID | 32111213 |
| Year | 2020 |
| Title | METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST |
External Links
| Links for METTL14 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |