Basic Information
| LncRNA/CircRNA Name | MEG8 |
| Synonyms | Bsr, Irm, LINC00024, NCRNA00024, Rian, SNHG23, SNHG24, lnc-MGC |
| Region | GRCh38_14:100894770-101038859 |
| Ensemble | ENSG00000225746 |
| Refseq | NR_024149 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RIP, other |
| Sample | pancreatic cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | MEG8 overexpression specifically suppressed the expression of microRNA-34a and microRNA-203 genes, resulting in up-regulation of SNAIL family transcriptional repressor 1 (SNAI1) and SNAI2 transcription factors, which repressed expression of cadherin 1 (CDH1)/E-cadherin. Mechanistic investigations revealed that MEG8 associates with enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) protein and induces its recruitment to the regulatory regions of the two microRNA genes for histone H3 methylation and transcriptional repression. Interestingly, expression of both MEG8 and MEG3, but not each individually, could induce EMT-related cell morphological changes and increased cell motility in the absence of TGF-? by activating the gene expression program required for EMT. MEG8 knockdown indicated that endogenous MEG8 lncRNA is indispensable for TGF-?-induced EMT in A549 lung cancer and Panc1 pancreatic cancer cells. |
| Pubmed ID | 30262664 |
| Year | 2018 |
| Title | MEG8 Long Noncoding RNA Contributes to Epigenetic Progression of the Epithelial-Mesenchymal Transition of Lung and Pancreatic Cancer Cells |
External Links
| Links for MEG8 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |