Basic Information
| LncRNA/CircRNA Name | MEG4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Luciferase reporter assay etc. |
| Sample | gastric cancer tissues and normal tissues. ,human gastric cancer cell lines (BGC-823, SGC- 7910, MGC-803 and AGS) and normal human gastric mucosa cell line (GES 1) |
| Expression Pattern | up-regulated |
| Function Description | MEG3 and ATP4B were downregulated in gastric cancer tissues compared with normal tissues.ATP4B might be regulated by targeting miR-181a-5p. The overexpression of MEG3 and the application of 5-Aza treatment inhibited the migration, invasion and proliferation of MGC-803 cells and promoted apoptosis. In gastric cancer tissues, MEG3 is hypermethylated to decrease expression. Once the expression of MEG3 is restored or methylation is inhibited, tumor growth can be inhibited both in vivo and in vitro. |
| Pubmed ID | 31584879 |
| Year | 2019 |
| Title | Hypermethylated Long Noncoding RNA MEG3 Promotes the Progression of Gastric Cancer |
External Links
| Links for MEG4 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |