Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric cancer tissue, cell lines (SGC7901, BGC823, MKN45, HGC27, GES) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA MEG3 was highly expressed in the adjacent tissue, compared to the one in gastric cancer tissue. What?? more, we also found that overexpression of lncRNA MEG3 could decrease the proliferation and metastasis of gastric cancer cells. Finally, overexpression of lncRNA MEG3 could also increase the expression of p53. |
| Pubmed ID | 28975980 |
| Year | 2017 |
| Title | lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |