Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, ISH etc. |
| Sample | breast cancer tissues, cell lines (MCF-7, T47-D, T24, 5637, Du145 etc.) |
| Expression Pattern | down-regulated |
| Function Description | MEG3 mRNA is expressed in the normal human fibroblast cells but is undetectable in human cancer cell lines by Northern blot. |
| Pubmed ID | 14602737 |
| Year | 2003 |
| Title | A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |