Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot |
| Sample | U87 cell line |
| Expression Pattern | down-regulated |
| Function Description | The results demonstrated that MEG3 expression levels were increased in U87 cells following cisplatin treatment.Decreased MEG3-induced autophagy improved the chemosensitivity of U87 cells to cisplatin. |
| Pubmed ID | 28677749 |
| Year | 2017 |
| Title | Long non-coding RNA MEG3 contributes to cisplatin-induced apoptosis via inhibition of autophagy in human glioma cells. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |