Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot etc. |
| Sample | OSCC tissues, cell lines(SCC-15, CAL-27) |
| Expression Pattern | down-regulated |
| Function Description | Importantly, MEG3 played a role as a tumor suppressor by inhibiting the WNT/B-catenin signaling pathway. In addition, the expression of the MEG3 was signifcantly affected by the degree of DNA methylation. It was concluded that the lncRNA MEG3 can inhibit the growth and metastasis of OSCC by negatively regulating the WNT/B-catenin signaling pathway. |
| Pubmed ID | 28953964 |
| Year | 2017 |
| Title | Long non-coding RNA MEG3 inhibits the proliferation and metastasis of oral squamous cell carcinoma by regulating the WNT/B-catenin signaling pathway |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |