Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | blood,cell line (K562) |
| Expression Pattern | down-regulated |
| Function Description | The lower expression of MEG3 and TET2 in AML cell lines was detected by RT-qPCR.The stable MEG3, TET2 overexpression cell pools in K562 cells was successful established.After transfection, MTT assay revealed that cell growth was significantly increased in AML cell lines transfected with TET2 compared with controls. |
| Pubmed ID | 29029424 |
| Year | 2017 |
| Title | microRNA-22 can regulate expression of the long non-coding RNA MEG3 in acute myeloid leukemia |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |