Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | cell line (hFOB 1.19, U-2 OS) |
| Expression Pattern | down-regulated |
| Function Description | the expression level of MEG3 gene was increased while the expression level of miR-664a was decreased.In addition, changes in expression level of MEG3 and miR-644a interferes with the migration of osteosarcoma cells migration speed of osteosarcoma cells.As a result of this study, it was shown that the upregulated expression of miR-664a could have an inhibitory effect on MEG3 gene expression and migration of osteosarcoma cells. |
| Pubmed ID | 28669734 |
| Year | 2017 |
| Title | Inhibition of miR-664a interferes with the migration of osteosarcoma cells via modulation of MEG3. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |