Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 |
| Methods | Microarray, MSP-PCR, RNAi, Western blot etc. |
| Sample | TSCC tissues, cell lines (SCC-15, CAL27 etc.) |
| Expression Pattern | down-regulated |
| Function Description | We report here that miR-26a and lncRNA MEG3 gene expression were both strongly reduced in TSCC compared with levels in matched nonmalignant tissues, and combined low expression levels of both miR-26a and MEG3 emerged as an independent prognostic factor for poor clinical outcome in TSCC patients. |
| Pubmed ID | 24343426 |
| Year | 2014 |
| Title | Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for tongue squamous cell carcinoma | OMIM COSMIC |