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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	T-cell lymphoblastic lymphoma
ICD-0-3	NA
Methods	qPCR, Western blot, in vitro knockdown, etc.
Sample	T-LBL tissues, T-LBL cell lines (Jurkat and SUP-T1)
Expression Pattern	down-regulated
Function Description	Maternally expressed gene 3 (MEG3), is a lncRNA, that has a depressed expression in multiple tumor types, including T cell lymphoblastic lymphoma (T LBL). However, the molecular mechanisms that regulate the tumorigenic functions of MEG3 in T LBL remain largely unknown. In this study, we aimed to discover and identify the function of MEG3 in T LBL tumorigenesis, epithelial mesenchymal transition (EMT) and drug resistance, and explore their mechanisms of action. Knockdown MEG3 promoted the proliferation, migration, invasion, and drug resistance of T LBL cells while overexpression of MEG3 gets the opposite results. The mechanism study showed that decreased MEG3 expression in T LBL cells could activate PI3K/mTOR signaling pathways, increase the expression of p glycoprotein and affect the expression of EMT markers for transforming to mesenchymal cells in vitro and in vivo. Together, these results indicate that MEG3 could inhibit the migration, invasion, and drug resistance in T LBL cells by suppression of the PI3K/mTOR pathway. MEG3 might be a potential target, through which poor prognosis with high recurrence and drug resistance of T LBL in a clinical setting could be reversed.
Pubmed ID	30556337
Year	2018
Title	dactolisib

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