Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | NA |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, etc. |
| Sample | colorectal adenocarcinoma tissues, colorectal adenocarcinoma cell lines Hs 698.T, Hs 255.T and SNU-C1 |
| Expression Pattern | down-regulated |
| Function Description | MEG3 expression level was decreased in tumor tissues than that in adjacent healthy tissues. Serum level of MEG3 was lower in cancer patients than that in healthy controls, and the serum level decreased with the increased stage of primary tumor. Serum TGF-?1 can be used to predict colorectal adenocarcinoma and its prognosis accurately. MEG3 knockdown and SPHK1 overexpression promoted tumor cell proliferation, but inhibited cell apoptosis. MEG3 knockdown also increased the expression level of TGF-?1 and SPHK1. Treatment with TGF-?1 inhibitor reduced the expression level of SPHK1 but showed no significant effects on MEG3. SPHK1 overexpression showed no significant effects on MEG3 and TGF-?1 expression. |
| Pubmed ID | 30556866 |
| Year | 2018 |
| Title | Down regulation of lncRNA MEG3 promotes colorectal adenocarcinoma cell proliferation and inhibits the apoptosis by up-regulating TGF-?1 and its downstream sphingosine kinase 1 |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |