Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, Western blot, RNAi, RIP, other |
| Sample | GBC tissues and cell lines (NOZ, GBC-SD, SGC-996, EH-GB1, OCUG-1) |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of MEG3 inhibited GBC cell proliferation and invasion, induced cell apoptosis and decreased tumorigenicity in nude mice. Moreover, we found that MEG3 was associated with EZH2 and attenuated EZH2 by promoting its ubiquitination. Furthermore, MEG3 executed its functions via EZH2 to regulate the downstream target gene LATS2. Taken together, these findings suggest that MEG3 is an effective target for GBC therapy and may facilitate the development of lncRNA-directed diagnostics and therapeutics against GBC. |
| Pubmed ID | 30282996 |
| Year | 2018 |
| Title | Long Noncoding RNA MEG3 Regulates LATS2 by Promoting the Ubiquitination of EZH2 and Inhibits Proliferation and Invasion in Gallbladder Cancer |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |