Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot |
| Sample | Human OSCC cell lines (CAL-27, SCC-4, SCC-9 and SCC-25) and a normal oral mucosal epithelial cell line (human oral keratinocyte, HOK), Fresh frozen primary tumors and paired adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | the expression of BANCR was up-regulated in OSCC tissues and cell lines compared to the negative control. The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite was observed for the overexpression of BANCR. The results also showed that the expression of MAPK signaling related proteins (p-erk, p-akt and p-p-38) was positively correlated with that of BANCR. |
| Pubmed ID | 31654433 |
| Year | 2019 |
| Title | Long non-coding RNA BANCR promotes proliferation and migration in oral squamous cell carcinoma via MAPK signaling pathway |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |