Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | NA |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Oxaliplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RIP, Luciferase Reporter Assay, Western blot |
| Sample | colorectal cancer tissues, cell lines (SW480, HT29, HCT116, NCM460) |
| Expression Pattern | down-regulated |
| Function Description | MEG3 was down-regulated in oxaliplatin-resistant CRC tissues and cell lines. Low MEG3 expression was correlated with poor prognosis of CRC patients. MEG3 suppressed miR-141 expression in HCT116/OXA cells. The MEG3 level was remarkably associated with Lymph node metastasis. MEG3 overexpression remarkably enhanced oxaliplatin-induced apoptosis in HT29/OXA and HCT116/OXA cells. |
| Pubmed ID | 30119236 |
| Year | 2018 |
| Title | Overexpression of MEG3 sensitizes colorectal cancer cells to oxaliplatin through regulation of miR-141/PDCD4 axis. |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |