Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | NA |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | Luciferase reporter assay , RIP etc. |
| Sample | RCC and adjacent normal tissues ,human renal cancer cell lines (ACHN, 786-O, SN12PM6), normal renal epithelial cell line (HK-2), and human 293T cells |
| Expression Pattern | down-regulated |
| Function Description | miR-124 and MEG3 were both significantly reduced in RCC, and combined expression of miR-124 and MEG3 emerged as an independent prognostic factor in our RCC cohort.Overexpression of miR-124 or MEG3 inhibited cell proliferation, migration, and invasion in vitro, and restrained tumor growth in vivo.EZH2 knockdown induced the epigenetic silencing of miR-124 and MEG3 expression by H3K27me3. Besides, miR-124 directly targeted the TET1 transcript, and then the interaction resulted in the upregulation of MEG3.MEG3 induced p53 protein accumulation, whereas p53 was a positive transcriptional regulator of the miR-124.In addition, tumor-suppressive PTPN11 was identified as a direct target of miR-124, as well as the MEG3- and p53-regulated gene. |
| Pubmed ID | 31071531 |
| Year | 2019 |
| Title | Regulatory Network of Two Tumor-Suppressive Noncoding RNAs Interferes with the Growth and Metastasis of Renal Cell Carcinoma |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |