Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | NA |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | tumor tissues and adjacent healthy tissues ,human hepatocellular carcinoma cell lines(Hep G2, SNU-398, C3A ,normal liver tissue cell line AML12 ,each hepatocellular carcinoma patient and healthy control blood |
| Expression Pattern | down-regulated |
| Function Description | Expression level of MEG3 was significantly lower in tumor tissues than in adjacent healthy tissues.Serum level of MEG3 was also significantly lower in hepatocellular carcinoma patients than in normal controls.Serum level of MEG3 was a diagnostic and prognostic marker for hepatocellular carcinoma.MEG3 small interfering Ribonucleic Acid (siRNA) silencing promoted the proliferation, migration, and invasion of hepatocellular carcinoma cells , while TGF-? inhibitor treatment reduced those enhancing effects.MEG3 siRNA silencing also increased the expression level of TGF-?1. |
| Pubmed ID | 31089680 |
| Year | 2019 |
| Title | Downregulation of Long Non-Coding RNA MEG3 Promotes Proliferation, Migration, and Invasion of Human Hepatocellular Carcinoma Cells by Upregulating TGF-?1 |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |