Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | NA |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | CCA tissues ,matched adjacent nontumor bile duct tissues ,CCA cells (QBC939, TFK-1, HCCC-9810, RBE, and CCLP-1) ,human intrahepatic biliary epithelial cell (HIBEC) |
| Expression Pattern | down-regulated |
| Function Description | MEG3 expression was significantly downregulated in both CCA tissues and cells in comparison with that in nontumor controls, respectively, and this downexpression was prominently associated with advanced TNM stage, lymph node invasion, and poor survival.Moreover, decreased MEG3 was an independent forecaster of poor prognosis for CCA patients.Functionally, MEG3 overexpression inhibited CCA growth in vitro and in vivo.Enhanced MEG3 also suppressed migration and invasion of CCLP-1 and QBC939 cells by reversing epithelial-mesenchymal transition (EMT) process.On the contrary, the proliferation, metastasis, and EMT were facilitated via knocking down MEG3. IMEG3 caused tumor suppressive effects partly through mediating polycomb repressive complex 1. |
| Pubmed ID | 31119760 |
| Year | 2019 |
| Title | LncRNA-MEG3 Inhibits Cell Proliferation and Invasion by Modulating Bmi1/RNF2 in Cholangiocarcinoma |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |