Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | NA |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | choriocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot etc. |
| Sample | Human placental CC (JEG-3) cells and BeWo cells |
| Expression Pattern | up-regulated |
| Function Description | MEG3 upregulation reduced cell viability, inhibited proliferation, migration and invasion, and promoted apoptosis.Expression of miR-211 was upregulated after lncRNA MEG3 overexpression. Effects of lncRNA MEG3 overexpression were augmented by miR-211 overexpression, while they were declined by miR-211 silencing.Phosphorylated levels of PI3K, AKT, and AMP-activated protein kinase (AMPK) were decreased by lncRNA MEG3 overexpression via regulation of miR-211. |
| Pubmed ID | 31124134 |
| Year | 2019 |
| Title | Long Noncoding RNA MEG3 Is a Tumor Suppressor in Choriocarcinoma by Upregulation of microRNA-211 |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for choriocarcinoma | OMIM COSMIC |