Basic Information
| LncRNA/CircRNA Name | MEG3 |
| Synonyms | NA |
| Region | GRCh38_14:100779410-100861031 |
| Ensemble | ENSG00000214548 |
| Refseq | NR_002766 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | OC tissues and surgical marginal normal tissues , OC cell lines (ie, A2780, Caov-3, OVCAR-3, and SKOV-3) and human normal ovarian surface epithelial cell line. |
| Expression Pattern | down-regulated |
| Function Description | Underexpressed MEG3 and miR-219a-5p were significantly associated with unfavorable prognosis of patients with OC when compared with overexpressed MEG3 and miR-219a-5p.In addition, the OC cells transfected with si-MEG3 or miR-219a-5p inhibitor exhibited stronger viability, proliferation, invasion, and migration than untreated cells.The apoptotic percentage of OC cells was reduced observably under treatments of si-MEG3 and miR-219a-5p inhibitor.Moreover, MEG3 exerted modulatory effects on the expression of miR-219a-5p, and there was a sponging relationship between them.EGFR expression was modified by both MEG3 and miR-219a-5p significantly, and raising EGFR expression could changeover the impacts of MEG3 and miR-219a-5p on the above-mentioned activity of OC cells. |
| Pubmed ID | 31161607 |
| Year | 2019 |
| Title | lncRNA MEG3 Modified Epithelial-Mesenchymal Transition of Ovarian Cancer Cells by Sponging miR-219a-5p and Regulating EGFR |
External Links
| Links for MEG3 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |